This leads to decreased GLP-1R degradation and increased chronic insulin secretion that is also observed upon silencing of -arrestin proteins [45]
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The proposed site of action is intracellular: fluorescently labeled short peptides have been reported to appear in the nuclei and nucleoli of cultured cells, and the same line of work described sequence-selective binding between labeled short peptides and synthetic deoxyribooligonucleotides in vitro