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A 2025 prospective RCT randomized 100 overweight/obese women with PCOS to either metformin alone (1,000 mg twice daily) or metformin + semaglutide 1 mg weekly for 16 weeks
Timing varies significantly between individuals because semaglutide response depends on metabolic markers, insulin sensitivity, baseline inflammatory state, and genetic variation in GLP-1 receptor function
Presented for research literature review only Dierickx PJ et al
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Moreover, AMPK stimulates the activation of the cAMP/PKA pathway in brown adipocytes, triggering lipolysis through the release of free fatty acids and upregulation of uncoupling protein 1 (UCP1)
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