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AHI reduction: Tirzepatide 15mg reduced apnea-hypopnea events by approximately 25-30 per hour vs 5 per hour for placebo Responder rate: Around 42% of tirzepatide participants achieved complete or near-complete resolution of sleep apnea events Weight loss: Average 18% body weight reduction accompanied the AHI improvements, consistent with SURMOUNT-1 data at comparable doses Source: Malhotra et al., NEJM 2024 Sleep Apnea Dosing vs Weight Loss Dosing The titration schedule is the same for both indications
This causes barrier damage, irritation, and increased acne
And when you eat less, you also consume less water-rich food (like fruits, veggies, and soups), which can lead to dehydration
doi: 10.1113/jphysiol.1970.sp009155 11 DupreJRossSAWatsonDBrownJC
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