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Compared with placebo, waist circumference decreased from week 20 to 68 (mean difference, 9.7 cm

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Key priorities include: (i) reproductive-oriented RCTs with live birth or cumulative live birth as primary endpoints and standardized washout templates

3 Resistance to chemotherapy caused by detoxification by GSH has been postulated, 56 suggesting that there may be possible benefits of selectively decreasing intracellular GSH in tumors to enhance the therapeutic effect of chemotherapy

Rizk, Hitoshi Suzuki, Vladimir Tesa, Hernn Trimarchi, Xuelian Wei, Hong Zhang, and Jonathan Barratt, for the ORIGIN Phase 3 Trial Investigators PMID: 41196369 The rationale for atacicept in IgA nephropathy stems from the ability to neutralize BAFF and APRIL, key cytokines for the production of galactose-deficient IgA1 (Gd-IgA1), the autoantigen central to the disease cascade