Discuss transitioning to an FDA-approved medication
While the regulation of alpha-cell GLP-1 production remains poorly understood, several studies have demonstrated that experimentally induced islet stress (e.g., by a cytokine cocktail (60), streptozotocin (STZ) (61), or chronic hyperglycemia (59)) potently stimulates alpha-cell GLP-1 production
doi: 10.1007/S004050050231 136 CelikMTuncerASoyerOUSakesenCTanju BeslerHKalayciO
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Every compound in this class, from semaglutide to tirzepatide to these newer agents, causes nausea, vomiting, and diarrhea to some degree