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Because of these effects, semaglutide has gained attention not only for blood sugar control in diabetes but also for weight loss

Most high-quality research shows clear differences in average weight loss: Tirzepatide (Zepbound) In large clinical trials (SURMOUNT-1), tirzepatide produced 15% to 22.5% total body weight loss , depending on the dose4

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Current NHS eligibility criteria for semaglutide 2.4 mg (Wegovy) for weight management, according to NICE TA875, include: Body Mass Index (BMI) 35 kg/m with at least one weight-related comorbidity (such as type 2 diabetes, hypertension, dyslipidaemia, obstructive sleep apnoea) For people from certain high-risk ethnic groups (such as South Asian, Chinese, Black African, or African-Caribbean), lower BMI thresholds apply (typically reduced by 2.5 kg/m) Treatment must be prescribed within specialist weight management services only Treatment is limited to a maximum duration of 2 years Must be used as an adjunct to a reduced-calorie diet and increased physical activity Liraglutide 3 mg (Saxenda) availability varies significantly across NHS regions and is not routinely commissioned in many areas

Low levels of glutathione send messages to trigger apoptosis or cell death