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The model of the peptide 20GCGRG s complex was built using the cryo-EM structure of the GCGGCGRG s complex (PDB code: 6LMK) 4 as the starting point
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The trial was overseen and sponsored by Novo Nordisk
The agonistic activity of these hybrids were obtained by functional assays using cells expressing the GLP-1R and by measuring the receptor-mediated cAMP produced
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