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Fred Sattler at University of Southern California Keck School of Medicine

The label goes further: tolerance to the appetite effect usually develops within a few weeks, and when that happens the instruction is to stop the medication, not increase the dose

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This reduces the time available for water absorption in the colon, leading to loose stools

For instance, when initiating GLP-1 therapy, a gradual reduction in insulin doses can help prevent diabetic ketoacidosis