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Tryptophan was found to reduce wakefulness after sleep onset and increase sleep efficiency as measured with actigraphy in all participants and improve subjective sleep quality scores in those carrying the genetic variant of interest

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Lifelong PE was diagnosed by an experienced andrologist on the basis of the International Society of Sexual Medicine (ISSM) definitions 3 , including the evaluation of intravaginal ejaculatory latency time (IELT) by stopwatch 18

Be consistent for at least 812 weeks