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The medication has a half-life of about 3.4 hours and is administered as a once-daily injection before bedtime to mimic physiological GH release [6]

Neurobiol Dis 74:392405 Carvey P, Zhao C, Hendey B, Lum H, Trachtenberg J, Desai B et al (2005) 6hydroxydopamineinduced alterations in bloodbrain barrier permeability