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If you dont have enough B12, you can end up developing a certain kind of anemia known as megaloblastic anemia

5-Amino-1MQ functions as a selective inhibitor of Nicotinamide N-methyltransferase (NNMT), an enzyme involved in metabolism

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Groups at higher risk of deficiency include older adults (due to reduced stomach acid production), vegans and vegetarians, people with pernicious anaemia or gastrointestinal disorders affecting absorption, and those taking certain medications such as metformin or proton pump inhibitors

The aforementioned results were also observed in a population of patients presenting with Biermers disease (Table 3) [33]