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- Provides a source of glutathione, the body's master antioxidant
The Grx family of proteins plays a key role in the regulation of glutathionylation reactions ( Figure 3
This effect is achieved through the activation of signaling pathways such as the ERK1/2, PI3K/AKT, and cAMP/PKA/-cat-Ser675 pathways, which are mediated by GLP-1RAs
As a major hydroxy peroxide scavenger, GPX4 can suppress ferroptosis thus playing an essential role in HSCs homeostasis
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