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Bach1 induces the accumulation of lactate-mediated H4K12 lactylation at the promoter region of LRRC15, targeting CD248/GP130/JAK-STAT3 axis to influence the development of astrocytes [181]
BioDrugs 34, 1126
Studies in rodents have shown that feeding animals a high-fat diet lower ObRa levels within the hypothalamus 24,35 and, consistent with this, leptin transport is decreased in obese humans
We defined regions of interest (ROIs) using brain atlases 60,61,62
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