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Clin Exp Ophthalmol
del Giglio AB, Cubero Dde I, Lerner TG, Guariento RT, de Azevedo RG, Paiva H, Goldman C, Carelli B, Cruz FM, Schindler F, Pianowski L, de Matos LL, del Giglio A
Mazer CD, Hare GM, Connelly PW, Gilbert RE, Shehata N, Quan A, et al
A study in C57BL/6 mice with intragastric administration of allulose at doses of 1 and 3 g per kg body weight described an increased GLP-1 secretion and a transient reduction in food intake that was no longer observed when animal lacking a GLP-1 receptor were used (Reference Hayakawa, Hira and Nakamura16)
The near-balanced peptide was shown to be ~2-fold less potent at GLP-1R and ~10 fold less potent at GCGR than native ligands in cAMP synthesis ( vs control groups
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