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The choice of nasal route for drug administration is mainly determined by considering the physicochemical properties of drugs, including hydrophobicity and molecular size (McMartin et al., 1987)
Breaking any of them compromises the peptide, reduces potency, and can introduce safety concerns
Wegovy is FDA-approved for weight management
Now, however, those compounded versions will no longer be legal
Davies et al., JAMA (2021) The landmark SELECT trial found that semaglutide reduced the risk of major adverse cardiovascular events by 20% in adults with obesity and established heart disease
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