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The renal extraction and the natriuretic action of GLP-1 in Humans depend on interaction with the GLP-1 receptor

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Compared with the initiation of sulfonylurea, the addition of SGLT2is to GLP-1RA therapy was associated with a significantly lower incidence rate of the composite cardiovascular endpoint (9.9 versus 13.0 per 1,000 person-years

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