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The consumption of a high-fat diet (HFD) is strongly associated with this condition, leading to visceral obesity and insulin resistance, which can cause neurological issues such as anxiety and depression [3, 4] and may even contribute to the progression of Alzheimer's and Parkinsons disease [5, 6]

Since the great majority of circulating IGF-I is normally sequestered in IGFBP complexes, an analogue that escapes that buffering behaves very differently in any system containing binding proteins, and that is the reason the IGF 1 LR3 variant exists as a reagent at all