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Oral semaglutide has very specific administration instructions to ensure proper absorption: it should be taken with no more than 4 ounces of plain water at least 30 minutes before the first food, beverage, or other oral medications of the day

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The gastrointestinal tract is learning to function with slower emptying times, and the nervous system is recalibrating its expectations about how quickly food should move through the digestive system

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The anatomy of the stomach means that left-side sleeping positions the esophageal junction above the level of gastric acid, while right-side sleeping does the opposite and can worsen reflux significantly