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The GLP-1RA exenatide was shown to significantly lower BMI and 2-hour glucose in adolescents with obesity, in the placebo-controlled, randomized controlled trial Combat-JUDO
Author Contributions N.Y
Second, decreased expression or serine phosphorylation of IRS proteins 44,45 can reduce their binding to PI3K, thereby down-regulating PI3K activation and inducing apparent IR
28,29 Although highly effective, 30 patients must administer injections of exenatide multiple times a day leading to low patient compliance
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