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PTIP, PARP1 and CHD4 deficiency in BRCA-deficient cells prevent the recruitment of the MRE11 nuclease to stall replication forks and subsequently protect nascent DNA from degradation, thus conferring chemoresistance and PARPi resistance [78]

Its best known for its role in collagen production, gene modulation and reducing inflammation, which is why become a popular ingredient in skincare products

Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center

Intracellular GSH/GSSG measurement The GSH and GSSG levels in whole liver tissues or cultured cells were measured using OxiSelect Total Glutathione (GSSG/GSH) Assay Kits in accordance with the manufacturers instructions (Cell Biolabs, San Diego, CA, USA)

Researchers use it as a model compound for copper-dependent signaling, geneexpression studies, and extracellular matrix research