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In the SUSTAIN and PIONEER trials, semaglutide delivered by injection and orally significantly reduced hsCRP levels in subjects with T2D, although the reduction was not statistically significant compared to active comparators in all trials [9]
High levels of sugar in the blood (hyperglycemia) and insulin deficiency or resistance can lead to increased oxidative stress
GLP-1 drugs do not work alone While the drugs can promote weight loss, they generally are not considered a standalone treatment for obesity
Tiredness may result from reduced caloric intake due to appetite suppression, gastrointestinal side effects limiting food consumption, dehydration from vomiting or diarrhea, changes in blood glucose levels, or metabolic adjustments during significant weight loss
Many people take an SSRI like Lexapro alongside tirzepatide without trouble
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