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However, "long-term" doesn't necessarily mean "forever." Some patients successfully maintain weight loss after discontinuation through sustained behavioral changes, consistent exercise routines, and modified dietary patterns developed during therapy
(PubMed) Haskell CF, Robertson B, Jones E, et al
With a combination protocol that may produce more rapid weight loss than monotherapy, the risk is theoretically higher
Weight loss inevitably involves some lean mass loss, and resistance training is the most effective countermeasure
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