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Aging is associated with reduced MOTS-c levels in certain tissues, including the skeletal muscle, and in circulation 15,19
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Rare but serious gastrointestinal adverse effects reported with GLP-1 receptor agonists include pancreatitis, gallbladder disease (cholecystitis, cholelithiasis), and severe delayed gastric emptying
The Fab7F38-bound GLP-1R is crystallized in a closed conformation with the ECDs peptide-binding area sealed, in line with the non-competitive property of Fab7F38
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