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When GLP-1 is released, it does four main things in the body: Signals the pancreas to release insulin when blood sugar is elevated Suppresses the release of glucagon (a hormone that raises blood sugar) Slows the rate at which food leaves the stomach Acts on appetite centres in the brain to promote feelings of fullness The GLP-1 your body produces gets broken down within a couple of minutes of being released
The good news: Lipfendra lowered Lp(a) too, by roughly a quarter in the main trials
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For researchers just starting their retatrutide dose escalation at 1-2mg weekly, this margin of error can be significant
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