And clinical trials of linsitinib showed a prolonged overall survival of in advanced high IGF-1R expression solid tumors (including lung cancer, melanoma, pancreatic cancer, and gastrointestinal stromal tumors) (Jones et al., 2015
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This increase in SNAC was not considered clinically relevant as it has no anticipated pharmacodynamic effects [37]
Under conditions of chronic energy flux constriction, compartment-specific regeneration efficiency may therefore become more relevant than bulk metabolite concentration
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