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Tips for Staying on Track A few simple habits make tirzepatide treatment smoother and more effective: Start low and go slow
A phase 3 2021 clinical trial found the mean weight loss on 2.4 milligram weekly injections of GLP-1 was 14.9% versus 2.4% with placebo after 68 weeks among people with a body mass index (BMI) of 30 or greater
However, benchmarking against SUSTAIN-6 flagged disagreement for the effect on all-cause mortality, highlighting potential residual confounding for this secondary endpoint that could reflect preferential prescribing in patients for whom clinicians anticipated limited life expectancy
This might be due to changes in hydration levels or the bodys metabolism as it adjusts to the medication
Specifically, it acts as an agonist (activator) for the glucagon-like peptide-1 (GLP-1) receptor and the glucose-dependent insulinotropic polypeptide (GIP) receptor
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