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Route of Administration The same peptide can have very different effective half-lives depending on how it's delivered: Intravenous : Fastest onset, shortest duration the peptide enters circulation immediately and is subject to full first-pass clearance Subcutaneous : Slower absorption from the injection site creates a depot effect, often extending effective duration Intramuscular : Similar to subcutaneous but with slightly different absorption kinetics Intranasal : Rapid absorption, bypasses the blood-brain barrier for some peptides, but bioavailability can be variable Oral : Most peptides are destroyed in the GI tract

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St Clair, D

In another study (159), Kubo et al