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10.1016/j.ctim.2019.102273 Complement Ther Med
[9] For methylation-focused NNMT studies, stronger experimental designs may include SAM, SAH, SAM/SAH ratio, nicotinamide, 1-methylnicotinamide, NAD + , global DNA methylation, locus-specific DNA methylation, histone methylation markers, RNA expression profiling, and tissue-specific analysis where relevant
Our mechanistic investigations revealed that intracellular GSSG elevation sensitizes hepatocytes to TNF killing by inducing IKK--SSG formation, leading to suppressed NF-B activation
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