The 1st glutathione-interaction site, also termed glutathione-scaffold site, is rather well defined and comprises several protein areas that altogether contribute to catalysis by interacting with the glutathione moiety of GSSR 7,8,13,14,15,35 , therefore explaining the specificity for the -glutamyl moiety 9,49,50
N Engl J Med 323:565570
Because glutathione is so active in the liver, people living in urban environments or those with demanding lifestyles often find their glutathione stores are used up more quickly than they can be replenished
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