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One major difference lies in early developmental history

2.2 Characteristics of heat stress-induced injury and compensatory responses in the testicular spermatogenic microenvironment 2.2.1 Characteristics of heat stressinduced testicular injury Heat stress-induced damage to the male reproductive system is mainly characterized by cell type specificity, temperature- and time-dependent effects, and the distinction between reversible and irreversible injuries

However, the difference in the net absorption was estimated to be smaller (approximately one-tenth) due to much longer transit in the colon than in the small intestine 273,274,275

A 30-day follow-up found no significant changes in selected liver and kidney laboratory markers, but the group was small and the duration was insufficient to define long-term safety

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