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Supplementary Table 7 (download XLSX MV4;11 CRBN -KO cells expressing ENLTagBFPP2AmCherry were transduced with a DMS library, which reintroduced CRBN with single-amino-acid substitutions within a 10- radius of the thalidomide-binding site
pubs.acs.org Lau DCW, et al
Vitamin C can step in and donate an electron to glutathione, "recycling" it back into its active, reduced state
Additionally, ROS promotes pro-inflammatory signaling (e.g., NF-B activation) and endothelial adhesion molecule expression (e.g., VCAM-1, ICAM-1, TNF-), further exacerbating vascular stiffness and atherosclerosis (Zeng and Yang, 2024)
Unpredictable Allergic Reactions: Resealing the leaky gut with zeolite prevents large, undigested food proteins from entering the bloodstream, where they would otherwise be flagged as allergens and trigger systemic MCAS flares
