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Both medications affect different systems in the body and can influence appetite, mood, and gastrointestinal function in distinct ways
DOI: 10.1161/JAHA.122.026728 [Google Scholar] Pan X, Yue L, Ban J, Ren L, Chen S
Retatrutide is a triple receptor agonist that activates GLP-1, GIP, and glucagon receptors simultaneously, whereas semaglutide activates only the GLP-1 receptor and tirzepatide activates both GLP-1 and GIP receptors
For a broader look at the topic, see our guide on can you donate blood while taking GLP-1 medications
1 Direct receptor effects , more speculative research has explored GLP-1 receptor expression in dermal fibroblasts and adipose-derived stem cells, theorizing that receptor activation could alter local cytokine signaling in the scalp, though this remains an active area of investigation rather than established fact
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