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Injection bypasses this uncertainty entirely

Bioavailability is the ability of a drug or other substance to be absorbed and used by the body. Intramuscular injections with a needle offer anywhere from 75% to 100% much higher bioavailability

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Patients with low energy, those over 40 (B12 absorption decreases with age), vegetarians/vegans (limited dietary B12), patients on metformin or PPI medications (which decrease B12 absorption), patients on weight management programs, and anyone wanting energy and metabolic support

Semaglutide: Drug information