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Metabolic brain disease, 37(2), 451462

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Whilst these results are notable, direct comparisons with currently approved agents should be interpreted with caution: such comparisons are indirect, based on different trial designs, populations, durations, and background interventions (including lifestyle counselling provided alongside study drug), and cannot be treated as equivalent to head-to-head evidence

2 Molecules with effects on two peptide hormone receptors in this instance, tirzepatide activates both the GLP1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

Presented for research literature review only Hung CF et al