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In particular, USP22 raised GSH content and reduced the occurrence of ferroptosis in cardiomyocytes by activating the Sirt1-p53/SLC7A11 axis [252]

Commonly reported side effects include nausea (2533%) , diarrhea (1823%) , and vomiting (813%) , mostly during the dose-escalation phase

When these systems are disrupted, no amount of calorie restriction produces sustainable results

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That's a meaningful body of circumstantial evidence, but it's not the same as clinical proof of efficacy in humans