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Furthermore, the strong sequence homology within the catalytic core contributes to substantial challenges in achieving isoform-selective inhibition and often results in off-target engagement, a major factor underlying the clinical failure of PDE-targeted therapeutics (Goff et al., 2009
DuanHNingMZouQYeYFengYZhangLet al
(2010) Development of Hepatitis C Virus Genotyping by Real-Time PCR Based on the NS5B Region
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