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FDA-Approved Uses As of 2026, tirzepatide (Zepbound) carries two FDA-approved indications: Chronic weight management approved November 2023 for adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related comorbidity such as high blood pressure, type 2 diabetes, or high cholesterol
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They usually contain a local anesthetic, and in some cases, a corticosteroid to help reduce inflammation
Journal of Investigative Dermatology, 141 (4), 1063-1070
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