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As shown in Figures 5D,E and Figure S4C in Supplementary Material, GSTP-S184D performed stronger inhibitory effect on LPS-induced HMGB1 release than GSTP (WT) in primary peritoneal macrophages, and RAW 264.7 and THP-1 cells, but GSTP-S184A showed a smaller influence
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This transparent approach is critical when working with a compound that is attracting significant interest in the context of weight management research
In the present study, we attempt to screen for small-molecule GLP-1R agonists by CMap which is an online pharmacogenomic database links disease, genes and drugs by identifying similar or opposite gene expression profiles
Similarly, Jardi et al
