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However, there is also a possibility that some of the effect may be independent of GLP-1, because DPP-4 inhibition still reduced -cell apoptosis in human islets cultured in the presence of exendin 9-39 (99), suggesting that other mediators might be involved, but it was also suggested that an anti-inflammatory action could have played a role (99)
Microdosing, however, is not an FDA-approved strategy
Dosages are typically adjusted before adding another medication
Jastreboff et al., NEJM (SURMOUNT-1): tirzepatide in adults with obesity or overweight (without diabetes)
He advises patients to aim for working out 3-5 times per week for 30 minutes at a time
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