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The greater decrease in LAC levels in severe forms of MDD and in patients with treatment resistant depression (TRD) is akin to a kindling-like progression of depression in that earlier age at onset and/or the presence of early life adversity, such as emotional trauma, conveys liability to more severe and treatment-resistant course of illness [51, 53, 55]
Acknowledgments The authors would like to extend their sincere appreciation to the funding agency Anusandhan National Research Foundation (ANRF), Science and Engineering Research Board (SERB), State University Research Excellence (SURE) & Empowerment and Equity Opportunities for Excellence in Science, New Delhi, India
Injection record: log date, time, and any missed or delayed dose
While phase 3 TRIUMPH trials are outputting positive data, the drug must complete its full testing program and undergo a formal FDA safety and manufacturing review before it hits pharmacy shelves
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