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Electrophysiological recordings revealed that exendin-4 increases the frequency of spontaneous excitatory postsynaptic currents (sEPSCs) of VTA dopaminergic neurons suggesting the possible presynaptic modulation of GLP-1R on glutamatergic terminals

PMID: 28 GersteinHCColhounHMDagenaisGRDiazRLakshmananMPaisPet al

Blood samples for C-peptide were drawn in serum clot activator tubes coated with microscopic silica particles (Greiner Bio-one, Frickenhausen, Germany) and were set to clot for 30 min at room temperature before centrifugation

Gastrointestinal side effects occur in roughly 20 to 30 percent of users and are described as often mild, dose-dependent, and frequently better on an extended-release formulation