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Rothberg has a patient who was struggling with weight and poor glycemic control, who was taking around 100 units of insulin, oral anti-diabetic medications, and anti-hypertensive medications
Combined with the appetite suppression from the GLP-1 pathway, this dual mechanism produces faster and more substantial weight loss for many patients
These changes can shift the makeup of the microbiome
Similarly, ophthalmological endpoints were investigated adjusting for (1) papilledema degree, (2) pRNFL thickness, (3) GCL volume, or (3) ONSD at baseline as appropriate and in a second step also for weight loss to evaluate potential independent treatment effects of GLP-1-RAs
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