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In summary, for patients with depression, neuroinflammationprimarily driven by the chronic activation of glial cellsinduces a cascade of structural and functional alterations across key emotion- and cognition-regulating brain regions (Slcudean et al., 2025
Safety animal and some human data profiles generally look good, but clinical fertility trials are sparse
The apoplastic generation of ROS occurs mainly by enzymes like membrane NADPH-dependent oxidase, cell wall peroxidase or polyamine oxidases (Bolwell et al., 1994)
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Finally, an area of substantial neglect is our understanding of the extent to which enzymes involved in trace amine synthesis and metabolism, may be affected in ASD
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