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10.1111/j.1365-313X.2008.03410.x 115 MeraR.TorresE.AbaldeJ

Carnitine in the blood is wasted via the urine so plasma levels of both free and acylated carnitine are extremely low (free carnitine T (p.P479L) variant in these populations causes a partially reduced CPT1A activity and is associated with infant mortality [87,88,89,90]

For topical products, the relevant question is not plasma half life but dermal residence time, which depends almost entirely on the delivery vehicle