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Also, in DURATION-8, a significantly higher proportion of participants lost at least 5% of body weight when treated with the combination of exenatide QW and dapagliflozin as compared to either exenatide or dapagliflozin (30.7%, 14.1%, and 21.3%, respectively) 17
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In a phase I trial of CB-839 in relapsed leukemia, patients receiving CB-839 treatment usually showed grade 1 or 2 toxicities like transaminitis, thrombocytopenia, gastrointestinal events, and fatigue and about 1/3 (9/26) patients showed grade 3 or 4 toxicities like hematologic cytopenia [63]
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