REDEFINE 2 Trial Type 2 Diabetes with Obesity The companion REDEFINE 2 trial, also published in 2025, enrolled 1,206 adults with type 2 diabetes and obesity or overweight, demonstrating the combinations efficacy in this more metabolically compromised population: Mean weight loss of 13.7% compared to 3.4% with placebo over 68 weeks 73.5% achieved hemoglobin A1c of 6.5% or less compared to 15.9% with placebo Greater proportions reaching multiple weight thresholds including 5%, 10%, 15%, and 20% reduction Significant glycemic improvement with mean A1c reduction demonstrating disease modification potential Favorable metabolic profile changes including improvements in blood pressure and lipids These findings established that the combination maintains substantial efficacy even in patients with the metabolic dysfunction of established type 2 diabetes, a population often showing reduced response to weight-loss interventions

Careful technique protects peptide performance during clinical research use
Key Research Characteristics: Selective NNMT inhibition, supporting studies into NAD metabolism and methylation pathways Investigated in the context of obesity, metabolic dysfunction, and lipid accumulation models Cell-permeable small molecule with favourable in vitro profile Studied for potential effects on adipocyte differentiation and energy expenditure Specifications: Form: Lyophilised powder For research purposes only
Bacteriostatic water is usable for 28 days after opening due to its benzyl alcohol preservative
Peptides limit complement activation and reduce phagocytosis risk by vaginal leukocytes