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A 10-year longitudinal follow-up study conducted at our research center on a cohort consisting of 159 patients with PCOS exhibited that long-term metformin treatment in overweight-obese women with PCOS led to a reduction and stabilization of body weight ( The weight trajectory after discontinuation of short-term semaglutide treatment in obese women with PCOS who continued metformin treatment has not yet been evaluated, so we can only provide a comparison with the general population from the STEP 1 extension study
[14] It's also important to emphasize that tirzepatide is not FDA-approved for the treatment of hypertension, and should not replace standard antihypertensive therapy
This, in turn, lowers cytokines that worsen insulin resistance
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