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In the 72-week SURMOUNT-5 trial described in this article, average weight reduction was 20.2% with tirzepatide and 13.7% with semaglutide among adults with obesity without type 2 diabetes
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Its primary physiological role involves stimulating insulin secretion from pancreatic beta cells in a glucose-dependent manner, which has made GLP-1 receptor agonists valuable therapeutic agents for type 2 diabetes mellitus
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