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Hormonal Modulation Retas unique ability to interact with multiple receptor types provides a framework for studying hormonal cross-talk, especially how GLP-1, GIP, and glucagon signaling affect one another in metabolic tissues

This work was supported by the National Natural Science Foundation of China (32171187 to YJ, 32130022 to HEX, 82121005 to XX, and HEX, 82330113 to XX, 82304579 to SMG)

March 5, 2013

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IGF-1 LR3 has two molecular modifications, an arginine substitution at position 3 and a 13-amino acid N-terminal extension, that prevent IGFBP binding