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While these products are marketed with claims about increasing melanin production, questions remain regarding their effectiveness, quality, and long-term safety

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Sharma A (2023) Mitochondrial cargo export in exosomes: possible pathways and implication in disease biology

It increases VEGF receptor activity to promote new blood vessel formation, enhances collagen synthesis and organization, activates the ERK1/2 signaling pathway for cell proliferation and migration, and modulates inflammatory responses to optimize healing conditions

Sikiri has said the risk is "entirely excluded," based on a cell study from 2004 a statement widely criticised, because the human safety data simply are not there